Search results for "oral glucose tolerance test"

showing 3 items of 3 documents

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

2014

Objective: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggested to lead to glucose intolerance and beta-cell dysfunction. However, recent reports comparing Bl/6J to Bl/6N (carrying the wild-type Nnt allele) under normal diet have led to conflicting results using glucose tolerance tests. Thus, we assessed glucose-stimulated insulin secretion (GSIS), insulin sensitivity, clearance and central glucose-induced insulin secretion in Bl/6J and N mice using gold-standard methodologies. Methods: GSIS was measured u…

Genetically modified mouseFSIVGTT frequently sampled intravenous glucose tolerance testmedicine.medical_specialtylcsh:Internal medicineinsulin secretionNormal dietDI disposition indexOGTT oral glucose tolerance testmedicine.medical_treatment[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutritionbeta-cellBrief Communicationmedicine.disease_cause[ SDV.BA ] Life Sciences [q-bio]/Animal biologyGSIS glucose-stimulated insulin secretiongenetic backgroundGIR glucose infusion rateInternal medicinemedicineInsulin-degrading enzymeIDE insulin degrading enzymeFood and Nutritioninsulin sensitivityInsulin secretionlcsh:RC31-1245Molecular BiologyEndocrinology and metabolismMutationMI insulin sensitivity indexbusiness.industryInsulin[SDV.BA]Life Sciences [q-bio]/Animal biologyInsulin sensitivityCell BiologyNNT nicotinamide nucleotide transhydrogenaseEndocrinologyIVGTT intravenous glucose tolerance testAlimentation et NutritionEndocrinologie et métabolismemouse strainBeta cellbusiness[SDV.AEN]Life Sciences [q-bio]/Food and Nutritionbeta-cell;insulin secretion;insulin sensitivity;genetic background;mouse strain
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Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331…

2015

Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions.

Maleendocrine system diseasesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentGlobal Health0302 clinical medicineEndocrinologyeducation.field_of_studyDiabetis//purl.org/pe-repo/ocde/ford#3.02.18 [https]Diabetes Mellitus/blood/diagnosis/epidemiologySciences bio-médicales et agricolesadultosensibilidad y especificidadhealth survey3. Good healthpriority journalCARDIOVASCULAR-DISEASEdiabetes mellitusmedicine.medical_specialtyglucosa sanguíneaSurvey samplingoral glucose tolerance test.Medical sciencesSensitivity and SpecificityArticleEndocrinology Diabetes and Metabolism; Internal Medicine; EndocrinologyEffects of diabetesHemoglobin A Glycosylated/metabolism03 medical and health sciencesfalse positive resultSDG 3 - Good Health and Well-beingDiabetes prevalenceDiabetes MellitusSYSTEMATIC ANALYSISHumanshumandiagnostic test accuracy studygross national productOLDER-ADULTSeducationprueba de tolerancia a la glucosaglycosylated hemoglobinHEMOGLOBIN A(1C) MEASUREMENTVLAGGlycated HemoglobinHemoglobin A GlycosylatedScience & TechnologyBlood Glucose/metabolismnutritional and metabolic diseasesGlucose Tolerance Testeconomic aspectmedicine.diseaseglucose blood levelGlucoseEndocrinologyagechemistryFaculdade de Ciências SociaisGlucosaGlobal surveillance of diabetesTOLERANCE TESTWORLDWIDE STANDARDIZATIONBiomarkersBiomedical sciencesBlood GlucoseSettore MED/09 - Medicina InternaNutrition and DiseasehumanosBiomarkers/metabolismInternal Medicine; Endocrinology Diabetes and Metabolism; Endocrinologygeographychemistry.chemical_compoundVoeding en ZiekteDiagnosisPrevalenceMedicine and Health Sciencesvigilancia centinela030212 general & internal medicinehemoglobin A1cUS POPULATIONDiabetes diagnosisGlucose tolerance testINSULIN-RESISTANCEmedicine.diagnostic_testResearch Support Non-U.S. Gov'tQDiabetesprevalenciaSCREENING-TESThealthArticlesGlucose bloodDiabetes and MetabolismincomePopulation-based health examination surveysFemaleLife Sciences & BiomedicineAdultPopulationpopulation groupCONSENSUS STATEMENT030209 endocrinology & metabolismGLYCATED HEMOGLOBINhigh income regionEndocrinology & MetabolismInsulin resistanceResearch Support N.I.H. ExtramuralbloodInternal medicineDiabetes mellitusparasitic diseasesJournal ArticlemedicineInternal MedicineLife Scienceddc:613business.industryInsulinbody massBiological markerFASTING PLASMA-GLUCOSECiencias socio biomédicasGlycated hemoglobinbusinessmetabolismSentinel Surveillance
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The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart.

2004

Aim The objective behind the Euro Heart Survey on diabetes and the heart was to study the prevalence of abnormal glucose regulation in adult patients with coronary artery disease (CAD). Methods and results The survey engaged 110 centres in 25 countries recruiting 4196 patients referred to a cardiologist due to CAD out of whom 2107 were admitted on an acute basis and 2854 had an elective consultation. Patient data were collected via a web-based case record form. An oral glucose tolerance test (OGTT) was used for the characterisation of the glucose metabolism. Thirty-one per cent of the patients had diabetes. An OGTT was performed on the 1920 patients without known diabetes, of whom 923 had a…

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